E3 ubiquitin-protein ligase NEDD4

Intermolecular

Cysteine 1286 and cysteine 305 of Polyubiquitin-B

A redox-regulated disulphide may form between cysteine 1286 of E3 ubiquitin-protein ligase NEDD4 and cysteine 305 of Polyubiquitin-B (866 and 76 respectively in this structure).

Details

Redox score ?

PDB code

4bbn

Structure name

nedd4 hect-ub:ub complex

Structure deposition date

2012-09-27

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide A name

E3 ubiquitin-protein ligase NEDD4

Peptide B name

Polyubiquitin-B

Peptide A accession

P46934

Peptide B accession

P0CG53

Peptide A residue number

1286

Peptide B residue number

305

Ligandability

Cysteine 1286 of E3 ubiquitin-protein ligase NEDD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.