ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Galanin receptor type 1

Intramolecular
Cysteine 108 and cysteine 187
Cysteine 217 and cysteine 219
A redox-regulated disulphide may form within Galanin receptor type 1 between cysteines 108 and 187.

Details

Redox score ?
82
PDB code
7wq3
Structure name
galanin-bound galanin receptor 1 in complex with gi
Structure deposition date
2022-01-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P47211
Residue number A
108
Residue number B
187
Peptide name
Galanin receptor type 1

Ligandability

Cysteine 108 of Galanin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Galanin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galanin receptor type 1 between cysteines 217 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7wq3
Structure name
galanin-bound galanin receptor 1 in complex with gi
Structure deposition date
2022-01-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
43
Peptide accession
P47211
Residue number A
217
Residue number B
219
Peptide name
Galanin receptor type 1

Ligandability

Cysteine 217 of Galanin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Galanin receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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