ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Guanine nucleotide exchange factor MSS4

Intramolecular
Cysteine 23 and cysteine 26
Cysteine 26 and cysteine 94
Cysteine 23 and cysteine 94
Cysteine 23 and cysteine 97
Cysteine 94 and cysteine 97
Cysteine 26 and cysteine 97
A redox-regulated disulphide may form within Guanine nucleotide exchange factor MSS4 between cysteines 23 and 26.

Details

Redox score ?
82
PDB code
1hxr
Structure name
crystal structure of mss4 at 1
Structure deposition date
2001-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
32
Peptide accession
Q08326
Residue number A
23
Residue number B
26
Peptide name
Guanine nucleotide exchange factor MSS4

Ligandability

Cysteine 23 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 26 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor MSS4 between cysteines 26 and 94.

Details

Redox score ?
80
PDB code
2fu5
Structure name
structure of rab8 in complex with mss4
Structure deposition date
2006-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
40
Peptide accession
P47224
Residue number A
26
Residue number B
94
Peptide name
Guanine nucleotide exchange factor MSS4

Ligandability

Cysteine 26 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 94 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor MSS4 between cysteines 23 and 94.

Details

Redox score ?
79
PDB code
2fu5
Structure name
structure of rab8 in complex with mss4
Structure deposition date
2006-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
6
% buried
51
Peptide accession
P47224
Residue number A
23
Residue number B
94
Peptide name
Guanine nucleotide exchange factor MSS4

Ligandability

Cysteine 23 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 94 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor MSS4 between cysteines 23 and 97.

Details

Redox score ?
77
PDB code
2fu5
Structure name
structure of rab8 in complex with mss4
Structure deposition date
2006-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
6
% buried
84
Peptide accession
P47224
Residue number A
23
Residue number B
97
Peptide name
Guanine nucleotide exchange factor MSS4

Ligandability

Cysteine 23 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor MSS4 between cysteines 94 and 97.

Details

Redox score ?
76
PDB code
2fu5
Structure name
structure of rab8 in complex with mss4
Structure deposition date
2006-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
44
Peptide accession
P47224
Residue number A
94
Residue number B
97
Peptide name
Guanine nucleotide exchange factor MSS4

Ligandability

Cysteine 94 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor MSS4 between cysteines 26 and 97.

Details

Redox score ?
73
PDB code
1hxr
Structure name
crystal structure of mss4 at 1
Structure deposition date
2001-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
16
Peptide accession
Q08326
Residue number A
26
Residue number B
97
Peptide name
Guanine nucleotide exchange factor MSS4

Ligandability

Cysteine 26 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Guanine nucleotide exchange factor MSS4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: