ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytosolic phospholipase A2

Intramolecular
Cysteine 139 and cysteine 141
A redox-regulated disulphide may form within Cytosolic phospholipase A2 between cysteines 139 and 141 (1139 and 1141 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1cjy
Structure name
human cytosolic phospholipase a2
Structure deposition date
1999-04-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
14
Peptide accession
P47712
Residue number A
139
Residue number B
141
Peptide name
Cytosolic phospholipase A2

Ligandability

Cysteine 139 of Cytosolic phospholipase A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Cytosolic phospholipase A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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