ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glucagon receptor

Intramolecular
Cysteine 224 and cysteine 294
Cysteine 81 and cysteine 121
Cysteine 58 and cysteine 100
Cysteine 43 and cysteine 67
A redox-regulated disulphide may form within Glucagon receptor between cysteines 224 and 294.

Details

Redox score ?
87
PDB code
4l6r
Structure name
structure of the class b human glucagon g protein coupled receptor
Structure deposition date
2013-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P47871
Residue number A
224
Residue number B
294
Peptide name
Glucagon receptor

Ligandability

Cysteine 224 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucagon receptor between cysteines 81 and 121.

Details

Redox score ?
87
PDB code
5xf1
Structure name
structure of the full-length glucagon class b g protein-coupled receptor
Structure deposition date
2017-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P47871
Residue number A
81
Residue number B
121
Peptide name
Glucagon receptor

Ligandability

Cysteine 81 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucagon receptor between cysteines 58 and 100.

Details

Redox score ?
85
PDB code
5xez
Structure name
structure of the full-length glucagon class b g protein-coupled receptor
Structure deposition date
2017-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P47871
Residue number A
58
Residue number B
100
Peptide name
Glucagon receptor

Ligandability

Cysteine 58 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucagon receptor between cysteines 43 and 67.

Details

Redox score ?
82
PDB code
4lf3
Structure name
inhibitory mechanism of an allosteric antibody targeting the glucagon receptor
Structure deposition date
2013-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P47871
Residue number A
43
Residue number B
67
Peptide name
Glucagon receptor

Ligandability

Cysteine 43 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Glucagon receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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