ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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mRNA decay activator protein ZFP36L2

Intramolecular
Cysteine 168 and cysteine 174
Cysteine 159 and cysteine 168
Cysteine 197 and cysteine 206
Cysteine 206 and cysteine 212
Cysteine 197 and cysteine 212
Cysteine 159 and cysteine 174
A redox-regulated disulphide may form within mRNA decay activator protein ZFP36L2 between cysteines 168 and 174.

Details

Redox score ?
89
PDB code
1rgo
Structure name
structural basis for recognition of the mrna class ii au-rich element by the tandem zinc finger domain of tis11d
Structure deposition date
2003-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
6
% buried
15
Peptide accession
P47974
Residue number A
168
Residue number B
174
Peptide name
mRNA decay activator protein ZFP36L2

Ligandability

Cysteine 168 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36L2 between cysteines 159 and 168.

Details

Redox score ?
88
PDB code
1rgo
Structure name
structural basis for recognition of the mrna class ii au-rich element by the tandem zinc finger domain of tis11d
Structure deposition date
2003-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
13
Peptide accession
P47974
Residue number A
159
Residue number B
168
Peptide name
mRNA decay activator protein ZFP36L2

Ligandability

Cysteine 159 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 168 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36L2 between cysteines 197 and 206.

Details

Redox score ?
86
PDB code
1rgo
Structure name
structural basis for recognition of the mrna class ii au-rich element by the tandem zinc finger domain of tis11d
Structure deposition date
2003-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
14
Peptide accession
P47974
Residue number A
197
Residue number B
206
Peptide name
mRNA decay activator protein ZFP36L2

Ligandability

Cysteine 197 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36L2 between cysteines 206 and 212.

Details

Redox score ?
85
PDB code
1rgo
Structure name
structural basis for recognition of the mrna class ii au-rich element by the tandem zinc finger domain of tis11d
Structure deposition date
2003-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
22
Peptide accession
P47974
Residue number A
206
Residue number B
212
Peptide name
mRNA decay activator protein ZFP36L2

Ligandability

Cysteine 206 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36L2 between cysteines 197 and 212.

Details

Redox score ?
84
PDB code
1rgo
Structure name
structural basis for recognition of the mrna class ii au-rich element by the tandem zinc finger domain of tis11d
Structure deposition date
2003-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
23
Peptide accession
P47974
Residue number A
197
Residue number B
212
Peptide name
mRNA decay activator protein ZFP36L2

Ligandability

Cysteine 197 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36L2 between cysteines 159 and 174.

Details

Redox score ?
81
PDB code
1rgo
Structure name
structural basis for recognition of the mrna class ii au-rich element by the tandem zinc finger domain of tis11d
Structure deposition date
2003-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
22
Peptide accession
P47974
Residue number A
159
Residue number B
174
Peptide name
mRNA decay activator protein ZFP36L2

Ligandability

Cysteine 159 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of mRNA decay activator protein ZFP36L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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