ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cytochrome b-c1 complex subunit Rieske, mitochondrial

Intramolecular
Cysteine 217 and cysteine 236
Cysteine 222 and cysteine 238
Cysteine 217 and cysteine 222
Cysteine 222 and cysteine 236
Cysteine 217 and cysteine 238
Cysteine 236 and cysteine 238
Cysteine 217 and cysteine 217
Cysteine 35 and cysteine 376
A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 217 and 236 (139 and 158 respectively in this structure).

Details

Redox score ?
81
PDB code
1l0n
Structure name
native structure of bovine mitochondrial cytochrome bc1 complex
Structure deposition date
2002-02-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
36
Peptide accession
P13272
Residue number A
217
Residue number B
236
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 217 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 236 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 222 and 238 (144 and 160 respectively in this structure).

Details

Redox score ?
79
PDB code
7o3h
Structure name
murine ciii2 focus-refined from supercomplex ciciii2
Structure deposition date
2021-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9CR68
Residue number A
222
Residue number B
238
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 222 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 238 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 217 and 222 (139 and 144 respectively in this structure).

Details

Redox score ?
75
PDB code
1l0n
Structure name
native structure of bovine mitochondrial cytochrome bc1 complex
Structure deposition date
2002-02-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
nan
Peptide accession
P13272
Residue number A
217
Residue number B
222
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 217 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 222 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 222 and 236 (144 and 158 respectively in this structure).

Details

Redox score ?
70
PDB code
1l0n
Structure name
native structure of bovine mitochondrial cytochrome bc1 complex
Structure deposition date
2002-02-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
nan
Peptide accession
P13272
Residue number A
222
Residue number B
236
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 222 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 236 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 217 and 238 (139 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7o3h
Structure name
murine ciii2 focus-refined from supercomplex ciciii2
Structure deposition date
2021-04-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
7
% buried
nan
Peptide accession
Q9CR68
Residue number A
217
Residue number B
238
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 217 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 238 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 236 and 238 (158 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7tay
Structure name
bos taurus mitochondrial bc1 in complex with pyramoxadone
Structure deposition date
2021-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
18
% buried
nan
Peptide accession
P13272
Residue number A
236
Residue number B
238
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 236 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 238 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 217 and 217 (346 and 411 respectively in this structure).

Details

Redox score ?
nan
PDB code
1bcc
Structure name
cytochrome bc1 complex from chicken
Structure deposition date
1998-03-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
96
Peptide accession
P13272
Residue number A
217
Residue number B
217
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 217 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 217 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Uncertain whether structure cysteine 346 has been assigned to correct residue.
Uncertain whether structure cysteine 411 has been assigned to correct residue.
A redox-regulated disulphide may form within Cytochrome b-c1 complex subunit Rieske, mitochondrial between cysteines 35 and 376.

Details

Redox score ?
nan
PDB code
1bcc
Structure name
cytochrome bc1 complex from chicken
Structure deposition date
1998-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
94
Peptide accession
P13272
Residue number A
35
Residue number B
376
Peptide name
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Ligandability

Cysteine 35 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 376 of Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cysteine 35 in protein A could not be asigned to a Uniprot residue.
Cysteine 376 in protein B could not be asigned to a Uniprot residue.
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