a tool for identifying drug-targetable redox-active disulphides

G protein-activated inward rectifier potassium channel 2

Intramolecular

Cysteine 134 and cysteine 166

A redox-regulated disulphide may form within G protein-activated inward rectifier potassium channel 2 between cysteines 134 and 166.

Details

Redox score ?

91

PDB code

Structure name

crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3

Structure deposition date

2011-07-16

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

134

Residue number B

166

Peptide name

G protein-activated inward rectifier potassium channel 2

Ligandability

Cysteine 134 of G protein-activated inward rectifier potassium channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of G protein-activated inward rectifier potassium channel 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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