ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Carboxypeptidase A2

Intramolecular
Cysteine 320 and cysteine 354
Cysteine 248 and cysteine 271
A redox-regulated disulphide may form within Carboxypeptidase A2 between cysteines 320 and 354 (210 and 244 respectively in this structure).

Details

Redox score ?
87
PDB code
1aye
Structure name
human procarboxypeptidase a2
Structure deposition date
1997-11-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48052
Residue number A
320
Residue number B
354
Peptide name
Carboxypeptidase A2

Ligandability

Cysteine 320 of Carboxypeptidase A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Carboxypeptidase A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Carboxypeptidase A2 between cysteines 248 and 271 (138 and 161 respectively in this structure).

Details

Redox score ?
84
PDB code
1aye
Structure name
human procarboxypeptidase a2
Structure deposition date
1997-11-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48052
Residue number A
248
Residue number B
271
Peptide name
Carboxypeptidase A2

Ligandability

Cysteine 248 of Carboxypeptidase A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Carboxypeptidase A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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