ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glioma pathogenesis-related protein 1

Intramolecular
Cysteine 131 and cysteine 135
Cysteine 192 and cysteine 201
Cysteine 75 and cysteine 156
Cysteine 195 and cysteine 206
Cysteine 192 and cysteine 195
Cysteine 151 and cysteine 173
Cysteine 192 and cysteine 206
Cysteine 195 and cysteine 201
Cysteine 37 and cysteine 151
Cysteine 201 and cysteine 206
Cysteine 37 and cysteine 173
A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 131 and 135.

Details

Redox score ?
89
PDB code
3q2r
Structure name
crystal structure of sglipr1 soaked with zinc chloride
Structure deposition date
2010-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
131
Residue number B
135
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 131 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 192 and 201.

Details

Redox score ?
87
PDB code
3q2r
Structure name
crystal structure of sglipr1 soaked with zinc chloride
Structure deposition date
2010-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
192
Residue number B
201
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 192 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 75 and 156.

Details

Redox score ?
85
PDB code
3q2r
Structure name
crystal structure of sglipr1 soaked with zinc chloride
Structure deposition date
2010-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
75
Residue number B
156
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 75 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 195 and 206.

Details

Redox score ?
85
PDB code
3q2u
Structure name
structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs
Structure deposition date
2010-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
195
Residue number B
206
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 195 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 192 and 195.

Details

Redox score ?
77
PDB code
3q2u
Structure name
structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs
Structure deposition date
2010-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
192
Residue number B
195
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 192 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 151 and 173.

Details

Redox score ?
76
PDB code
3q2r
Structure name
crystal structure of sglipr1 soaked with zinc chloride
Structure deposition date
2010-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
151
Residue number B
173
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 151 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 192 and 206.

Details

Redox score ?
70
PDB code
3q2u
Structure name
structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs
Structure deposition date
2010-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
192
Residue number B
206
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 192 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 195 and 201.

Details

Redox score ?
69
PDB code
3q2r
Structure name
crystal structure of sglipr1 soaked with zinc chloride
Structure deposition date
2010-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
195
Residue number B
201
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 195 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 37 and 151.

Details

Redox score ?
62
PDB code
3q2r
Structure name
crystal structure of sglipr1 soaked with zinc chloride
Structure deposition date
2010-12-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
nan
Peptide accession
P48060
Residue number A
37
Residue number B
151
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 37 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 201 and 206.

Details

Redox score ?
61
PDB code
3q2u
Structure name
structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs
Structure deposition date
2010-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48060
Residue number A
201
Residue number B
206
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 201 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glioma pathogenesis-related protein 1 between cysteines 37 and 173. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3q2u
Structure name
structure of human glioma pathogenesis-related protein 1 reveals unique loops and surface motifs
Structure deposition date
2010-12-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
nan
Peptide accession
P48060
Residue number A
37
Residue number B
173
Peptide name
Glioma pathogenesis-related protein 1

Ligandability

Cysteine 37 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Glioma pathogenesis-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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