Stromal cell-derived factor 1
Intermolecular
Cysteine 32 and cysteine 265
Cysteine 34 of Atypical chemokine receptor 3 and cysteine 55
Cysteine 71 and cysteine 265
Cysteine 65 and cysteine 55
Intramolecular
Cysteine 32 and cysteine 71
Cysteine 30 and cysteine 55
Cysteine 32 and cysteine 55
Cysteine 30 and cysteine 32
Cysteine 55 and cysteine 71
Cysteine 32 and cysteine 36
Cysteine 30 and cysteine 71
2k04 A 11 C 265
A redox-regulated disulphide may form between two units of Stromal cell-derived factor 1 at cysteines 32 and 265 (11 and 265 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
2k04
Structure name
structure of sdf1 in complex with the cxcr4 n-terminus containing no sulfotyrosines
Structure deposition date
2008-01-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Stromal cell-derived factor 1
Peptide B name
Stromal cell-derived factor 1
Peptide A accession
P48061
Peptide B accession
P48061
Peptide A residue number
32
Peptide B residue number
265
Ligandability
Cysteine 32 of Stromal cell-derived factor 1
Cysteine 265 of Stromal cell-derived factor 1
Cysteine 265 in protein B could not be asigned to a Uniprot residue.
7sk4 A 34 B 34
A redox-regulated disulphide may form between cysteine 34 of Atypical chemokine receptor 3 and cysteine 55 of Stromal cell-derived factor 1 (34 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7sk4
Structure name
cryo-em structure of ackr3 in complex with chemokine n-terminal mutant cxcl12_lrhq, an intracellular fab, and an extracellular fab
Structure deposition date
2021-10-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
nan
Peptide A name
Atypical chemokine receptor 3
Peptide B name
Stromal cell-derived factor 1
Peptide A accession
P25106
Peptide B accession
P48061
Peptide A residue number
34
Peptide B residue number
55
Ligandability
Cysteine 34 of Atypical chemokine receptor 3
Cysteine 55 of Stromal cell-derived factor 1
2k04 A 50 C 265
A redox-regulated disulphide may form between two units of Stromal cell-derived factor 1 at cysteines 71 and 265 (50 and 265 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
2k04
Structure name
structure of sdf1 in complex with the cxcr4 n-terminus containing no sulfotyrosines
Structure deposition date
2008-01-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Stromal cell-derived factor 1
Peptide B name
Stromal cell-derived factor 1
Peptide A accession
P48061
Peptide B accession
P48061
Peptide A residue number
71
Peptide B residue number
265
Ligandability
Cysteine 71 of Stromal cell-derived factor 1
Cysteine 265 of Stromal cell-derived factor 1
Cysteine 265 in protein B could not be asigned to a Uniprot residue.
2k03 A 65 C 234
A redox-regulated disulphide may form between two units of Stromal cell-derived factor 1 at cysteines 65 and 55 (65 and 234 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
2k03
Structure name
structure of sdf1 in complex with the cxcr4 n-terminus containing a sulfotyrosine at postition 21
Structure deposition date
2008-01-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Stromal cell-derived factor 1
Peptide B name
Stromal cell-derived factor 1
Peptide A accession
P48061
Peptide B accession
P48061
Peptide A residue number
65
Peptide B residue number
55
Ligandability
Cysteine 65 of Stromal cell-derived factor 1
Cysteine 55 of Stromal cell-derived factor 1
Cysteine 65 in protein A could not be asigned to a Uniprot residue.
3hp3 I 11 I 50
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 32 and 71 (11 and 50 respectively in this structure).
Details
Redox score ?
85
PDB code
3hp3
Structure name
crystal structure of cxcl12
Structure deposition date
2009-06-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ICW0
Residue number A
32
Residue number B
71
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 32 of Stromal cell-derived factor 1
Cysteine 71 of Stromal cell-derived factor 1
3hp3 H 9 H 34
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 30 and 55 (9 and 34 respectively in this structure).
Details
Redox score ?
84
PDB code
3hp3
Structure name
crystal structure of cxcl12
Structure deposition date
2009-06-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ICW0
Residue number A
30
Residue number B
55
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 30 of Stromal cell-derived factor 1
Cysteine 55 of Stromal cell-derived factor 1
4uai B 11 B 34
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 32 and 55 (11 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4uai
Structure name
crystal structure of cxcl12 in complex with inhibitor
Structure deposition date
2014-08-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48061
Residue number A
32
Residue number B
55
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 32 of Stromal cell-derived factor 1
Cysteine 55 of Stromal cell-derived factor 1
3hp3 J 9 J 11
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 30 and 32 (9 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3hp3
Structure name
crystal structure of cxcl12
Structure deposition date
2009-06-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ICW0
Residue number A
30
Residue number B
32
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 30 of Stromal cell-derived factor 1
Cysteine 32 of Stromal cell-derived factor 1
4lmq F 34 F 50
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 55 and 71 (34 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4lmq
Structure name
development and preclinical characterization of a humanized antibody targeting cxcl12
Structure deposition date
2013-07-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48061
Residue number A
55
Residue number B
71
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 55 of Stromal cell-derived factor 1
Cysteine 71 of Stromal cell-derived factor 1
2k04 A 11 A 36
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 32 and 36 (11 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2k04
Structure name
structure of sdf1 in complex with the cxcr4 n-terminus containing no sulfotyrosines
Structure deposition date
2008-01-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48061
Residue number A
32
Residue number B
36
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 32 of Stromal cell-derived factor 1
Cysteine 36 of Stromal cell-derived factor 1
Cysteine 36 in protein B could not be asigned to a Uniprot residue.
3hp3 B 9 B 50
A redox-regulated disulphide may form within Stromal cell-derived factor 1 between cysteines 30 and 71 (9 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3hp3
Structure name
crystal structure of cxcl12
Structure deposition date
2009-06-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ICW0
Residue number A
30
Residue number B
71
Peptide name
Stromal cell-derived factor 1
Ligandability
Cysteine 30 of Stromal cell-derived factor 1
Cysteine 71 of Stromal cell-derived factor 1
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