Glycine receptor subunit beta

Intramolecular

A redox-regulated disulphide may form within Glycine receptor subunit beta between cysteines 183 and 197 (161 and 175 respectively in this structure).

Details

Redox score ?

PDB code

5bkg

Structure name

cyro-em structure of human glycine receptor alpha2-beta heteromer, glycine bound, (semi)open state

Structure deposition date

2021-03-19

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P48167

Residue number A

183

Residue number B

197

Peptide name

Glycine receptor subunit beta

Ligandability

Cysteine 183 of Glycine receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Glycine receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycine receptor subunit beta between cysteines 243 and 255 (221 and 233 respectively in this structure).

Details

Redox score ?

PDB code

7kuy

Structure name

cyro-em structure of human glycine receptor alpha2-beta heteromer, strychnine bound state

Structure deposition date

2020-11-25

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P48167

Residue number A

243

Residue number B

255

Peptide name

Glycine receptor subunit beta

Ligandability

Cysteine 243 of Glycine receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Glycine receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycine receptor subunit beta between cysteines 313 and 336 (291 and 314 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?