ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gamma-aminobutyric acid receptor subunit alpha-4

Intramolecular
Cysteine 172 and cysteine 186
Cysteine 267 and cysteine 326
A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit alpha-4 between cysteines 172 and 186.

Details

Redox score ?
84
PDB code
7qna
Structure name
cryo-em structure of human full-length alpha4beta3gamma2 gaba(a)r in complex with gaba and nanobody nb25
Structure deposition date
2021-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48169
Residue number A
172
Residue number B
186
Peptide name
Gamma-aminobutyric acid receptor subunit alpha-4

Ligandability

Cysteine 172 of Gamma-aminobutyric acid receptor subunit alpha-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Gamma-aminobutyric acid receptor subunit alpha-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit alpha-4 between cysteines 267 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7qn7
Structure name
cryo-em structure of human full-length extrasynaptic alpha4beta3delta gaba(a)r in complex with gaba, histamine and nanobody nb25
Structure deposition date
2021-12-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
93
Peptide accession
P48169
Residue number A
267
Residue number B
326
Peptide name
Gamma-aminobutyric acid receptor subunit alpha-4

Ligandability

Cysteine 267 of Gamma-aminobutyric acid receptor subunit alpha-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Gamma-aminobutyric acid receptor subunit alpha-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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