ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gastric inhibitory polypeptide receptor

Intramolecular
Cysteine 84 and cysteine 118
Cysteine 61 and cysteine 103
Cysteine 46 and cysteine 70
Cysteine 216 and cysteine 286
A redox-regulated disulphide may form within Gastric inhibitory polypeptide receptor between cysteines 84 and 118.

Details

Redox score ?
87
PDB code
6dkj
Structure name
human gipr ecd and fab complex
Structure deposition date
2018-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48546
Residue number A
84
Residue number B
118
Peptide name
Gastric inhibitory polypeptide receptor

Ligandability

Cysteine 84 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gastric inhibitory polypeptide receptor between cysteines 61 and 103.

Details

Redox score ?
85
PDB code
6dkj
Structure name
human gipr ecd and fab complex
Structure deposition date
2018-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48546
Residue number A
61
Residue number B
103
Peptide name
Gastric inhibitory polypeptide receptor

Ligandability

Cysteine 61 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gastric inhibitory polypeptide receptor between cysteines 46 and 70.

Details

Redox score ?
82
PDB code
6dkj
Structure name
human gipr ecd and fab complex
Structure deposition date
2018-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P48546
Residue number A
46
Residue number B
70
Peptide name
Gastric inhibitory polypeptide receptor

Ligandability

Cysteine 46 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gastric inhibitory polypeptide receptor between cysteines 216 and 286.

Details

Redox score ?
74
PDB code
7fiy
Structure name
cryo-em structure of the tirzepatide-bound human gipr-gs complex
Structure deposition date
2021-08-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
53
Peptide accession
P48546
Residue number A
216
Residue number B
286
Peptide name
Gastric inhibitory polypeptide receptor

Ligandability

Cysteine 216 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Gastric inhibitory polypeptide receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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