Potassium voltage-gated channel subfamily C member 1
Intermolecular
Cysteine 83 and cysteine 105
Cysteine 78 and cysteine 83
Cysteine 104 and cysteine 83
Intramolecular
Cysteine 104 and cysteine 105
Cysteine 78 and cysteine 105
Cysteine 78 and cysteine 104
7pqt C 83 D 105
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily C member 1 at cysteines 83 and 105.
Details
Redox score ?
84
PDB code
7pqt
Structure name
apo human kv3
Structure deposition date
2021-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
2
% buried
88
Peptide A name
Potassium voltage-gated channel subfamily C member 1
Peptide B name
Potassium voltage-gated channel subfamily C member 1
Peptide A accession
P48547
Peptide B accession
P48547
Peptide A residue number
83
Peptide B residue number
105
Ligandability
Cysteine 83 of Potassium voltage-gated channel subfamily C member 1
Cysteine 105 of Potassium voltage-gated channel subfamily C member 1
7phi C 78 D 83
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily C member 1 at cysteines 78 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7phi
Structure name
human voltage-gated potassium channel kv3
Structure deposition date
2021-08-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
88
Peptide A name
Potassium voltage-gated channel subfamily C member 1
Peptide B name
Potassium voltage-gated channel subfamily C member 1
Peptide A accession
Q3KNS8
Peptide B accession
Q3KNS8
Peptide A residue number
78
Peptide B residue number
83
Ligandability
Cysteine 78 of Potassium voltage-gated channel subfamily C member 1
Cysteine 83 of Potassium voltage-gated channel subfamily C member 1
7phl C 104 D 83
A redox-regulated disulphide may form between two units of Potassium voltage-gated channel subfamily C member 1 at cysteines 104 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7phl
Structure name
human voltage-gated potassium channel kv3
Structure deposition date
2021-08-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
19
% buried
nan
Peptide A name
Potassium voltage-gated channel subfamily C member 1
Peptide B name
Potassium voltage-gated channel subfamily C member 1
Peptide A accession
Q3KNS8
Peptide B accession
Q3KNS8
Peptide A residue number
104
Peptide B residue number
83
Ligandability
Cysteine 104 of Potassium voltage-gated channel subfamily C member 1
Cysteine 83 of Potassium voltage-gated channel subfamily C member 1
7phl B 104 B 105
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily C member 1 between cysteines 104 and 105.
Details
Redox score ?
68
PDB code
7phl
Structure name
human voltage-gated potassium channel kv3
Structure deposition date
2021-08-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
88
Peptide accession
Q3KNS8
Residue number A
104
Residue number B
105
Peptide name
Potassium voltage-gated channel subfamily C member 1
Ligandability
Cysteine 104 of Potassium voltage-gated channel subfamily C member 1
Cysteine 105 of Potassium voltage-gated channel subfamily C member 1
7phi B 78 B 105
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily C member 1 between cysteines 78 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7phi
Structure name
human voltage-gated potassium channel kv3
Structure deposition date
2021-08-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
17
% buried
nan
Peptide accession
Q3KNS8
Residue number A
78
Residue number B
105
Peptide name
Potassium voltage-gated channel subfamily C member 1
Ligandability
Cysteine 78 of Potassium voltage-gated channel subfamily C member 1
Cysteine 105 of Potassium voltage-gated channel subfamily C member 1
7phi D 78 D 104
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily C member 1 between cysteines 78 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
7phi
Structure name
human voltage-gated potassium channel kv3
Structure deposition date
2021-08-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
17
% buried
82
Peptide accession
Q3KNS8
Residue number A
78
Residue number B
104
Peptide name
Potassium voltage-gated channel subfamily C member 1
Ligandability
Cysteine 78 of Potassium voltage-gated channel subfamily C member 1
Cysteine 104 of Potassium voltage-gated channel subfamily C member 1
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