Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Intermolecular
Cysteine 524 and cysteine 120 of Phosphoinositide 3-kinase regulatory subunit 5
Cysteine 524 and cysteine 123 of Phosphoinositide 3-kinase regulatory subunit 5
Intramolecular
Cysteine 932 and cysteine 936
Cysteine 936 and cysteine 1013
Cysteine 357 and cysteine 524
Cysteine 932 and cysteine 1013
Cysteine 936 and cysteine 1075
Cysteine 932 and cysteine 1075
Cysteine 275 and cysteine 296
Cysteine 863 and cysteine 932
Cysteine 1013 and cysteine 1075
7mez A 524 B 120
A redox-regulated disulphide may form between cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and cysteine 120 of Phosphoinositide 3-kinase regulatory subunit 5.
Details
Redox score ?
76
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
58
Peptide A name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Peptide B name
Phosphoinositide 3-kinase regulatory subunit 5
Peptide A accession
P48736
Peptide B accession
O02696
Peptide A residue number
524
Peptide B residue number
120
Ligandability
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 120 of Phosphoinositide 3-kinase regulatory subunit 5
7mez A 524 B 123
A redox-regulated disulphide may form between cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and cysteine 123 of Phosphoinositide 3-kinase regulatory subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7mez
Structure name
structure of the phosphoinositide 3-kinase p110 gamma (pik3cg) p101 (pik3r5) complex
Structure deposition date
2021-04-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
70
Peptide A name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Peptide B name
Phosphoinositide 3-kinase regulatory subunit 5
Peptide A accession
P48736
Peptide B accession
O02696
Peptide A residue number
524
Peptide B residue number
123
Ligandability
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 123 of Phosphoinositide 3-kinase regulatory subunit 5
4ps3 A 932 A 936
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 932 and 936.
Details
Redox score ?
65
PDB code
4ps3
Structure name
structure of pi3k gamma in complex with 1-[6-(5-methoxypyridin-3-yl)- 1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1h-imidazol-4-yl)ethyl]urea
Structure deposition date
2014-03-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
9
% buried
100
Peptide accession
P48736
Residue number A
932
Residue number B
936
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 932 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 936 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
4ps8 A 936 A 1013
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 936 and 1013.
Details
Redox score ?
60
PDB code
4ps8
Structure name
structure of pi3k gamma in complex with n-[6-(5,6-dimethoxypyridin-3- yl)-1,3-benzothiazol-2-yl]acetamide
Structure deposition date
2014-03-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
100
Peptide accession
P48736
Residue number A
936
Residue number B
1013
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 936 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 1013 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
1e7v A 357 A 524
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 357 and 524. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
1e7v
Structure name
structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Structure deposition date
2000-09-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
35
Minimum pKa ?
9
% buried
4
Peptide accession
O02697
Residue number A
357
Residue number B
524
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 357 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 524 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
1e7u A 932 A 1013
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 932 and 1013. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
1e7u
Structure name
structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Structure deposition date
2000-09-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
O02697
Residue number A
932
Residue number B
1013
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 932 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 1013 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
6c1s A 936 A 1075
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 936 and 1075. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6c1s
Structure name
phosphoinositide 3-kinase gamma bound to an pyrrolopyridinone inhibitor
Structure deposition date
2018-01-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
98
Peptide accession
P48736
Residue number A
936
Residue number B
1075
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 936 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 1075 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
3qar A 932 A 1075
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 932 and 1075. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
3qar
Structure name
crystal structure of pi3k-gamma in complex with triazine-benzimidazole 32
Structure deposition date
2011-01-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
98
Peptide accession
P48736
Residue number A
932
Residue number B
1075
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 932 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 1075 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
3apf A 275 A 296
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 275 and 296. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3apf
Structure name
crystal structure of human pi3k-gamma in complex with ch5039699
Structure deposition date
2010-10-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
55
Peptide accession
P48736
Residue number A
275
Residue number B
296
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 275 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 296 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
3mjw A 863 A 932
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 863 and 932. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
3mjw
Structure name
pi3 kinase gamma with a benzofuranone inhibitor
Structure deposition date
2010-04-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
9
% buried
97
Peptide accession
P48736
Residue number A
863
Residue number B
932
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 863 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 932 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
6c1s A 1013 A 1075
A redox-regulated disulphide may form within Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform between cysteines 1013 and 1075. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6c1s
Structure name
phosphoinositide 3-kinase gamma bound to an pyrrolopyridinone inhibitor
Structure deposition date
2018-01-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
98
Peptide accession
P48736
Residue number A
1013
Residue number B
1075
Peptide name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ligandability
Cysteine 1013 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cysteine 1075 of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
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