a tool for identifying drug-targetable redox-active disulphides

DNA polymerase delta subunit 2

Intermolecular

Cysteine 314 and cysteine 314

Intramolecular

Cysteine 438 and cysteine 447

Cysteine 92 and cysteine 177 L

Cysteine 91 and cysteine 92 L

A redox-regulated disulphide may form between two units of DNA polymerase delta subunit 2 at cysteines 314 and 314. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

52

PDB code

Structure name

x-ray structure of the complex of regulatory subunits of human dna polymerase delta

Structure deposition date

2008-07-31

Thiol separation (Å)

5

Half-sphere exposure sum ?

76

Minimum pK_a ?

13

% buried

100

Peptide A name

DNA polymerase delta subunit 2

Peptide B name

DNA polymerase delta subunit 2

Peptide A accession

Peptide B accession

Peptide A residue number

314

Peptide B residue number

314

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA polymerase delta subunit 2 between cysteines 438 and 447.

Details

Redox score ?

67

PDB code

Structure name

human polymerase delta-fen1-pcna toolbelt

Structure deposition date

2019-12-10

Thiol separation (Å)

4

Half-sphere exposure sum ?

76

Minimum pK_a ?

8

% buried

91

Peptide accession

Residue number A

438

Residue number B

447

Peptide name

DNA polymerase delta subunit 2

Ligandability

Cysteine 438 of DNA polymerase delta subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 447 of DNA polymerase delta subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA polymerase delta subunit 2 between cysteines 92 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

49

PDB code

Structure name

x-ray structure of the complex of regulatory subunits of human dna polymerase delta

Structure deposition date

2008-07-31

Thiol separation (Å)

6

Half-sphere exposure sum ?

73

Minimum pK_a ?

12

% buried

70

Peptide accession

Residue number A

92

Residue number B

177

Peptide name

DNA polymerase delta subunit 2

Ligandability

Cysteine 92 of DNA polymerase delta subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 177 of DNA polymerase delta subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA polymerase delta subunit 2 between cysteines 91 and 92. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

46

PDB code

Structure name

x-ray structure of the complex of regulatory subunits of human dna polymerase delta

Structure deposition date

2008-07-31

Thiol separation (Å)

8

Half-sphere exposure sum ?

74

Minimum pK_a ?

11

% buried

60

Peptide accession

Residue number A

91

Residue number B

92

Peptide name

DNA polymerase delta subunit 2

Ligandability

Cysteine 91 of DNA polymerase delta subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 92 of DNA polymerase delta subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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