ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Guided entry of tail-anchored proteins factor CAMLG

Intermolecular
Cysteine 157 of Guided entry of tail-anchored proteins factor 1 and cysteine 275
Cysteine 162 of Guided entry of tail-anchored proteins factor 1 and cysteine 275
Intramolecular
Cysteine 208 and cysteine 284
A redox-regulated disulphide may form between cysteine 157 of Guided entry of tail-anchored proteins factor 1 and cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
18
Peptide A name
Guided entry of tail-anchored proteins factor 1
Peptide B name
Guided entry of tail-anchored proteins factor CAMLG
Peptide A accession
O00258
Peptide B accession
P49069
Peptide A residue number
157
Peptide B residue number
275

Ligandability

Cysteine 157 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 162 of Guided entry of tail-anchored proteins factor 1 and cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
52
Peptide A name
Guided entry of tail-anchored proteins factor 1
Peptide B name
Guided entry of tail-anchored proteins factor CAMLG
Peptide A accession
O00258
Peptide B accession
P49069
Peptide A residue number
162
Peptide B residue number
275

Ligandability

Cysteine 162 of Guided entry of tail-anchored proteins factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Guided entry of tail-anchored proteins factor CAMLG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guided entry of tail-anchored proteins factor CAMLG between cysteines 208 and 284.

Details

Redox score ?
86
PDB code
6so5
Structure name
homo sapiens wrb/caml heterotetramer in complex with a trc40 dimer
Structure deposition date
2019-08-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49069
Residue number A
208
Residue number B
284
Peptide name
Guided entry of tail-anchored proteins factor CAMLG

Ligandability

Cysteine 208 of Guided entry of tail-anchored proteins factor CAMLG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Guided entry of tail-anchored proteins factor CAMLG

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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