a tool for identifying drug-targetable redox-active disulphides

Nuclear receptor subfamily 2 group C member 2

Intramolecular

Cysteine 434 and cysteine 479

A redox-regulated disulphide may form within Nuclear receptor subfamily 2 group C member 2 between cysteines 434 and 479 (453 and 498 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

crystal structure of the ligand binding domain of human testicular receptor 4

Structure deposition date

2010-09-29

Thiol separation (Å)

8

Half-sphere exposure sum ?

53

Minimum pK_a ?

10

% buried

54

Peptide accession

Residue number A

434

Residue number B

479

Peptide name

Nuclear receptor subfamily 2 group C member 2

Ligandability

Cysteine 434 of Nuclear receptor subfamily 2 group C member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 479 of Nuclear receptor subfamily 2 group C member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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