MAP kinase-activated protein kinase 2

Intramolecular

A redox-regulated disulphide may form within MAP kinase-activated protein kinase 2 between cysteines 98 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6tca

Structure name

phosphorylated p38 and mapkapk2 complex with inhibitor

Structure deposition date

2019-11-05

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P49137

Residue number A

Residue number B

133

Peptide name

MAP kinase-activated protein kinase 2

Ligandability

Cysteine 98 of MAP kinase-activated protein kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.