ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Parathyroid hormone 2 receptor

Intramolecular
Cysteine 86 and cysteine 125
Cysteine 63 and cysteine 103
Cysteine 236 and cysteine 306
Cysteine 48 and cysteine 72
A redox-regulated disulphide may form within Parathyroid hormone 2 receptor between cysteines 86 and 125.

Details

Redox score ?
87
PDB code
7f16
Structure name
cryo-em structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein
Structure deposition date
2021-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49190
Residue number A
86
Residue number B
125
Peptide name
Parathyroid hormone 2 receptor

Ligandability

Cysteine 86 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Parathyroid hormone 2 receptor between cysteines 63 and 103.

Details

Redox score ?
86
PDB code
7f16
Structure name
cryo-em structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein
Structure deposition date
2021-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49190
Residue number A
63
Residue number B
103
Peptide name
Parathyroid hormone 2 receptor

Ligandability

Cysteine 63 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Parathyroid hormone 2 receptor between cysteines 236 and 306.

Details

Redox score ?
85
PDB code
7f16
Structure name
cryo-em structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein
Structure deposition date
2021-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49190
Residue number A
236
Residue number B
306
Peptide name
Parathyroid hormone 2 receptor

Ligandability

Cysteine 236 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Parathyroid hormone 2 receptor between cysteines 48 and 72.

Details

Redox score ?
84
PDB code
7f16
Structure name
cryo-em structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein
Structure deposition date
2021-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49190
Residue number A
48
Residue number B
72
Peptide name
Parathyroid hormone 2 receptor

Ligandability

Cysteine 48 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Parathyroid hormone 2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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