a tool for identifying drug-targetable redox-active disulphides

Deoxyhypusine synthase

Intramolecular

Cysteine 97 and cysteine 275

A redox-regulated disulphide may form within Deoxyhypusine synthase between cysteines 97 and 275.

Details

Redox score ?

67

PDB code

Structure name

deoxyhypusine synthase holoenzyme in its low ionic strength, high ph crystal form with the inhibitor gc7 bound in the active site

Structure deposition date

2003-12-04

Thiol separation (Å)

4

Half-sphere exposure sum ?

80

Minimum pK_a ?

7

% buried

76

Peptide accession

Residue number A

97

Residue number B

275

Peptide name

Deoxyhypusine synthase

Ligandability

Cysteine 97 of Deoxyhypusine synthase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Deoxyhypusine synthase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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