ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine--tRNA ligase, cytoplasmic

Intramolecular
Cysteine 46 and cysteine 117
Cysteine 395 and cysteine 398
A redox-regulated disulphide may form within Serine--tRNA ligase, cytoplasmic between cysteines 46 and 117.

Details

Redox score ?
75
PDB code
3vbb
Structure name
crystal structure of seryl-trna synthetase from human at 2
Structure deposition date
2012-01-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
12
Peptide accession
P49591
Residue number A
46
Residue number B
117
Peptide name
Serine--tRNA ligase, cytoplasmic

Ligandability

Cysteine 46 of Serine--tRNA ligase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Serine--tRNA ligase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine--tRNA ligase, cytoplasmic between cysteines 395 and 398. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
4rqe
Structure name
human seryl-trna synthetase dimer complexed with two molecules of trnasec
Structure deposition date
2014-11-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
P49591
Residue number A
395
Residue number B
398
Peptide name
Serine--tRNA ligase, cytoplasmic

Ligandability

Cysteine 395 of Serine--tRNA ligase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Serine--tRNA ligase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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