DNA primase small subunit
Intramolecular
Cysteine 121 and cysteine 131
Cysteine 121 and cysteine 122
Cysteine 121 and cysteine 128
Cysteine 122 and cysteine 128
Cysteine 122 and cysteine 131
Cysteine 128 and cysteine 131
Cysteine 167 and cysteine 170
4rr2 A 121 A 131
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 121 and 131.
Details
Redox score ?
90
PDB code
4rr2
Structure name
crystal structure of human primase
Structure deposition date
2014-11-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
3
% buried
54
Peptide accession
P49642
Residue number A
121
Residue number B
131
Peptide name
DNA primase small subunit
Ligandability
Cysteine 121 of DNA primase small subunit
Cysteine 131 of DNA primase small subunit
5exr E 121 E 122
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 121 and 122.
Details
Redox score ?
85
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
39
Peptide accession
P49642
Residue number A
121
Residue number B
122
Peptide name
DNA primase small subunit
Ligandability
Cysteine 121 of DNA primase small subunit
Cysteine 122 of DNA primase small subunit
6r4s E 121 E 128
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 121 and 128.
Details
Redox score ?
84
PDB code
6r4s
Structure name
crystal structure of the pri1 subunit of human primase bound to atp
Structure deposition date
2019-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
36
Peptide accession
P49642
Residue number A
121
Residue number B
128
Peptide name
DNA primase small subunit
Ligandability
Cysteine 121 of DNA primase small subunit
Cysteine 128 of DNA primase small subunit
6r5e E 122 E 128
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 122 and 128.
Details
Redox score ?
82
PDB code
6r5e
Structure name
crystal structure of the pri1 subunit of human primase bound to 2f-atp
Structure deposition date
2019-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
22
Peptide accession
P49642
Residue number A
122
Residue number B
128
Peptide name
DNA primase small subunit
Ligandability
Cysteine 122 of DNA primase small subunit
Cysteine 128 of DNA primase small subunit
5exr E 122 E 131
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 122 and 131.
Details
Redox score ?
80
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
49
Peptide accession
P49642
Residue number A
122
Residue number B
131
Peptide name
DNA primase small subunit
Ligandability
Cysteine 122 of DNA primase small subunit
Cysteine 131 of DNA primase small subunit
4bpu C 128 C 131
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 128 and 131.
Details
Redox score ?
78
PDB code
4bpu
Structure name
crystal structure of human primase in heterodimeric form, comprising pris and truncated pril lacking the c-terminal fe-s domain
Structure deposition date
2013-05-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
46
Peptide accession
P49642
Residue number A
128
Residue number B
131
Peptide name
DNA primase small subunit
Ligandability
Cysteine 128 of DNA primase small subunit
Cysteine 131 of DNA primase small subunit
5exr E 167 E 170
A redox-regulated disulphide may form within DNA primase small subunit between cysteines 167 and 170. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
5exr
Structure name
crystal structure of human primosome
Structure deposition date
2015-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
100
Peptide accession
P49642
Residue number A
167
Residue number B
170
Peptide name
DNA primase small subunit
Ligandability
Cysteine 167 of DNA primase small subunit
Cysteine 170 of DNA primase small subunit
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