ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcriptional repressor CTCF

Intramolecular
Cysteine 353 and cysteine 356
Cysteine 409 and cysteine 412
Cysteine 439 and cysteine 442
Cysteine 324 and cysteine 327
Cysteine 381 and cysteine 384
Cysteine 557 and cysteine 577
Cysteine 469 and cysteine 472
Cysteine 557 and cysteine 560
Cysteine 296 and cysteine 299
Cysteine 525 and cysteine 528
More...
Cysteine 560 and cysteine 577
Cysteine 497 and cysteine 500
A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 353 and 356.

Details

Redox score ?
98
PDB code
5t0u
Structure name
ctcf znf2-7 and dna complex structure
Structure deposition date
2016-08-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
0
% buried
59
Peptide accession
P49711
Residue number A
353
Residue number B
356
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 353 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 409 and 412.

Details

Redox score ?
94
PDB code
5k5h
Structure name
homo sapiens ccctc-binding factor (ctcf) znf4-7 and dna complex structure
Structure deposition date
2016-05-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
37
Minimum pKa ?
5
% buried
0
Peptide accession
P49711
Residue number A
409
Residue number B
412
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 409 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 412 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 439 and 442.

Details

Redox score ?
94
PDB code
5t0u
Structure name
ctcf znf2-7 and dna complex structure
Structure deposition date
2016-08-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
5
% buried
0
Peptide accession
P49711
Residue number A
439
Residue number B
442
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 439 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 442 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 324 and 327.

Details

Redox score ?
92
PDB code
5t0u
Structure name
ctcf znf2-7 and dna complex structure
Structure deposition date
2016-08-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
P49711
Residue number A
324
Residue number B
327
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 324 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 327 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 381 and 384.

Details

Redox score ?
92
PDB code
5t0u
Structure name
ctcf znf2-7 and dna complex structure
Structure deposition date
2016-08-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
P49711
Residue number A
381
Residue number B
384
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 381 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 557 and 577 (50 and 70 respectively in this structure).

Details

Redox score ?
92
PDB code
1x6h
Structure name
solution structures of the c2h2 type zinc finger domain of human transcriptional repressor ctcf
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
0
Peptide accession
P49711
Residue number A
557
Residue number B
577
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 557 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 577 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 469 and 472.

Details

Redox score ?
89
PDB code
5k5l
Structure name
homo sapiens ccctc-binding factor (ctcf) znf6-8 and h19 sequence dna complex structure
Structure deposition date
2016-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
7
% buried
0
Peptide accession
P49711
Residue number A
469
Residue number B
472
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 469 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 557 and 560 (50 and 53 respectively in this structure).

Details

Redox score ?
88
PDB code
1x6h
Structure name
solution structures of the c2h2 type zinc finger domain of human transcriptional repressor ctcf
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
0
Peptide accession
P49711
Residue number A
557
Residue number B
560
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 557 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 560 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 296 and 299.

Details

Redox score ?
88
PDB code
5t0u
Structure name
ctcf znf2-7 and dna complex structure
Structure deposition date
2016-08-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
6
% buried
0
Peptide accession
P49711
Residue number A
296
Residue number B
299
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 296 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 525 and 528 (18 and 21 respectively in this structure).

Details

Redox score ?
86
PDB code
1x6h
Structure name
solution structures of the c2h2 type zinc finger domain of human transcriptional repressor ctcf
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
7
% buried
0
Peptide accession
P49711
Residue number A
525
Residue number B
528
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 525 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 528 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 560 and 577 (53 and 70 respectively in this structure).

Details

Redox score ?
85
PDB code
1x6h
Structure name
solution structures of the c2h2 type zinc finger domain of human transcriptional repressor ctcf
Structure deposition date
2005-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
8
% buried
0
Peptide accession
P49711
Residue number A
560
Residue number B
577
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 560 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 577 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor CTCF between cysteines 497 and 500.

Details

Redox score ?
75
PDB code
5und
Structure name
crystal structure of ctcf(znf 4-10) with 28-mer dna
Structure deposition date
2017-01-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
28
Minimum pKa ?
8
% buried
0
Peptide accession
P49711
Residue number A
497
Residue number B
500
Peptide name
Transcriptional repressor CTCF

Ligandability

Cysteine 497 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 of Transcriptional repressor CTCF

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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