a tool for identifying drug-targetable redox-active disulphides

CCAAT/enhancer-binding protein alpha

Intermolecular

Cysteine 245 and cysteine 56

A redox-regulated disulphide may form between two units of CCAAT/enhancer-binding protein alpha at cysteines 245 and 56 (245 and 498 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

tribbles (trib1) pseudokinase fused to ccaat-enhancer binding protein (c/ebpalpha) degron

Structure deposition date

2018-05-03

Thiol separation (Å)

8

Half-sphere exposure sum ?

56

Minimum pK_a ?

10

% buried

58

Peptide A name

CCAAT/enhancer-binding protein alpha

Peptide B name

CCAAT/enhancer-binding protein alpha

Peptide A accession

Peptide B accession

Peptide A residue number

245

Peptide B residue number

56

Ligandability

Cysteine 245 of CCAAT/enhancer-binding protein alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of CCAAT/enhancer-binding protein alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 in protein A could not be asigned to a Uniprot residue.

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