ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Translation initiation factor eIF-2B subunit beta

Intermolecular
Cysteine 198 and cysteine 465 of Translation initiation factor eIF-2B subunit delta
Cysteine 194 and cysteine 465 of Translation initiation factor eIF-2B subunit delta
Intramolecular
Cysteine 194 and cysteine 198
Cysteine 194 and cysteine 310
A redox-regulated disulphide may form between cysteine 198 of Translation initiation factor eIF-2B subunit beta and cysteine 465 of Translation initiation factor eIF-2B subunit delta.

Details

Redox score ?
86
PDB code
7kmf
Structure name
sugar phosphate activation of the stress sensor eif2b
Structure deposition date
2020-11-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
4
% buried
66
Peptide A name
Translation initiation factor eIF-2B subunit beta
Peptide B name
Translation initiation factor eIF-2B subunit delta
Peptide A accession
P49770
Peptide B accession
Q9UI10
Peptide A residue number
198
Peptide B residue number
465

Ligandability

Cysteine 198 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 465 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 194 of Translation initiation factor eIF-2B subunit beta and cysteine 465 of Translation initiation factor eIF-2B subunit delta. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7kmf
Structure name
sugar phosphate activation of the stress sensor eif2b
Structure deposition date
2020-11-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
4
% buried
74
Peptide A name
Translation initiation factor eIF-2B subunit beta
Peptide B name
Translation initiation factor eIF-2B subunit delta
Peptide A accession
P49770
Peptide B accession
Q9UI10
Peptide A residue number
194
Peptide B residue number
465

Ligandability

Cysteine 194 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 465 of Translation initiation factor eIF-2B subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit beta between cysteines 194 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6o81
Structure name
electron cryo-microscopy of the eukaryotic translation initiation factor 2b bound to translation initiation factor 2 from homo sapiens
Structure deposition date
2019-03-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
92
Peptide accession
P49770
Residue number A
194
Residue number B
198
Peptide name
Translation initiation factor eIF-2B subunit beta

Ligandability

Cysteine 194 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit beta between cysteines 194 and 310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7f64
Structure name
eif2b-sfsv nss
Structure deposition date
2021-06-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
P49770
Residue number A
194
Residue number B
310
Peptide name
Translation initiation factor eIF-2B subunit beta

Ligandability

Cysteine 194 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Translation initiation factor eIF-2B subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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