Fms-related tyrosine kinase 3 ligand
Intramolecular
Cysteine 30 and cysteine 111
Cysteine 70 and cysteine 153
Cysteine 119 and cysteine 158
Cysteine 30 and cysteine 153
Cysteine 30 and cysteine 70
Cysteine 111 and cysteine 153
Cysteine 70 and cysteine 111
7qdp C 4 C 85
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 30 and 111 (4 and 85 respectively in this structure).
Details
Redox score ?
88
PDB code
7qdp
Structure name
crystal structure of flt3 t343i in complex with the canonical ligand fl
Structure deposition date
2021-11-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49771
Residue number A
30
Residue number B
111
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 30 of Fms-related tyrosine kinase 3 ligand
Cysteine 111 of Fms-related tyrosine kinase 3 ligand
3qs9 C 44 C 127
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 70 and 153 (44 and 127 respectively in this structure).
Details
Redox score ?
84
PDB code
3qs9
Structure name
crystal structure of a human flt3 ligand-receptor ternary complex
Structure deposition date
2011-02-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49771
Residue number A
70
Residue number B
153
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 70 of Fms-related tyrosine kinase 3 ligand
Cysteine 153 of Fms-related tyrosine kinase 3 ligand
7qdp C 93 C 132
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 119 and 158 (93 and 132 respectively in this structure).
Details
Redox score ?
78
PDB code
7qdp
Structure name
crystal structure of flt3 t343i in complex with the canonical ligand fl
Structure deposition date
2021-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
0
Peptide accession
P49771
Residue number A
119
Residue number B
158
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 119 of Fms-related tyrosine kinase 3 ligand
Cysteine 158 of Fms-related tyrosine kinase 3 ligand
3qs7 C 4 C 127
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 30 and 153 (4 and 127 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
3qs7
Structure name
crystal structure of a human flt3 ligand-receptor ternary complex
Structure deposition date
2011-02-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49771
Residue number A
30
Residue number B
153
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 30 of Fms-related tyrosine kinase 3 ligand
Cysteine 153 of Fms-related tyrosine kinase 3 ligand
3qs7 B 4 B 44
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 30 and 70 (4 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3qs7
Structure name
crystal structure of a human flt3 ligand-receptor ternary complex
Structure deposition date
2011-02-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49771
Residue number A
30
Residue number B
70
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 30 of Fms-related tyrosine kinase 3 ligand
Cysteine 70 of Fms-related tyrosine kinase 3 ligand
7qdp A 85 A 127
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 111 and 153 (85 and 127 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7qdp
Structure name
crystal structure of flt3 t343i in complex with the canonical ligand fl
Structure deposition date
2021-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49771
Residue number A
111
Residue number B
153
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 111 of Fms-related tyrosine kinase 3 ligand
Cysteine 153 of Fms-related tyrosine kinase 3 ligand
1ete D 44 D 85
A redox-regulated disulphide may form within Fms-related tyrosine kinase 3 ligand between cysteines 70 and 111 (44 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1ete
Structure name
crystal structure of the flt3 ligand
Structure deposition date
2000-04-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49771
Residue number A
70
Residue number B
111
Peptide name
Fms-related tyrosine kinase 3 ligand
Ligandability
Cysteine 70 of Fms-related tyrosine kinase 3 ligand
Cysteine 111 of Fms-related tyrosine kinase 3 ligand
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