ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Granzyme K

Intramolecular
Cysteine 149 and cysteine 220
Cysteine 181 and cysteine 199
Cysteine 210 and cysteine 234
Cysteine 52 and cysteine 68
A redox-regulated disulphide may form within Granzyme K between cysteines 149 and 220 (136 and 201 respectively in this structure).

Details

Redox score ?
87
PDB code
1mza
Structure name
crystal structure of human pro-granzyme k
Structure deposition date
2002-10-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49863
Residue number A
149
Residue number B
220
Peptide name
Granzyme K

Ligandability

Cysteine 149 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granzyme K between cysteines 181 and 199 (168 and 182 respectively in this structure).

Details

Redox score ?
81
PDB code
1mzd
Structure name
crystal structure of human pro-granzyme k
Structure deposition date
2002-10-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49863
Residue number A
181
Residue number B
199
Peptide name
Granzyme K

Ligandability

Cysteine 181 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granzyme K between cysteines 210 and 234 (191 and 220 respectively in this structure).

Details

Redox score ?
80
PDB code
1mza
Structure name
crystal structure of human pro-granzyme k
Structure deposition date
2002-10-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49863
Residue number A
210
Residue number B
234
Peptide name
Granzyme K

Ligandability

Cysteine 210 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granzyme K between cysteines 52 and 68 (42 and 58 respectively in this structure).

Details

Redox score ?
80
PDB code
1mzd
Structure name
crystal structure of human pro-granzyme k
Structure deposition date
2002-10-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49863
Residue number A
52
Residue number B
68
Peptide name
Granzyme K

Ligandability

Cysteine 52 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Granzyme K

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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