ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cytosolic purine 5'-nucleotidase

Intramolecular
Cysteine 48 and cysteine 336 L
A redox-regulated disulphide may form within Cytosolic purine 5'-nucleotidase between cysteines 48 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5cr7
Structure name
human cytosolic 5'-nucleotidase ii in complex with n-(9h-purin-6-yl)- 3-(3-pyrrol-1-ylphenyl)benzamide
Structure deposition date
2015-07-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
54
Peptide accession
P49902
Residue number A
48
Residue number B
336
Peptide name
Cytosolic purine 5'-nucleotidase

Ligandability

Cysteine 48 of Cytosolic purine 5'-nucleotidase

Cysteine 336 of Cytosolic purine 5'-nucleotidase

If this tool was useful for finding a disulphide, please cite: