ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cathelicidin antimicrobial peptide

Intramolecular
Cysteine 86 and cysteine 97
Cysteine 108 and cysteine 125
A redox-regulated disulphide may form within Cathelicidin antimicrobial peptide between cysteines 86 and 97.

Details

Redox score ?
88
PDB code
4eyc
Structure name
crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld)
Structure deposition date
2012-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49913
Residue number A
86
Residue number B
97
Peptide name
Cathelicidin antimicrobial peptide

Ligandability

Cysteine 86 of Cathelicidin antimicrobial peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Cathelicidin antimicrobial peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cathelicidin antimicrobial peptide between cysteines 108 and 125.

Details

Redox score ?
77
PDB code
4eyc
Structure name
crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld)
Structure deposition date
2012-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P49913
Residue number A
108
Residue number B
125
Peptide name
Cathelicidin antimicrobial peptide

Ligandability

Cysteine 108 of Cathelicidin antimicrobial peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Cathelicidin antimicrobial peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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