a tool for identifying drug-targetable redox-active disulphides

Matrix metalloproteinase-14

Intramolecular

Cysteine 319 and cysteine 508

A redox-regulated disulphide may form within Matrix metalloproteinase-14 between cysteines 319 and 508.

Details

Redox score ?

75

PDB code

Structure name

mt1-mmp hpx domain with blade 2 loop bound to nanodiscs

Structure deposition date

2018-03-02

Thiol separation (Å)

5

Half-sphere exposure sum ?

43

Minimum pK_a ?

9

% buried

10

Peptide accession

Residue number A

319

Residue number B

508

Peptide name

Matrix metalloproteinase-14

Ligandability

Cysteine 319 of Matrix metalloproteinase-14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of Matrix metalloproteinase-14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: