ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuropeptide Y receptor type 4

Intramolecular
Cysteine 114 and cysteine 201
Cysteine 61 and cysteine 64
Cysteine 91 and cysteine 316
Cysteine 91 and cysteine 94
Cysteine 94 and cysteine 122
A redox-regulated disulphide may form within Neuropeptide Y receptor type 4 between cysteines 114 and 201.

Details

Redox score ?
82
PDB code
7x9c
Structure name
cryo-em structure of neuropeptide y y4 receptor in complex with pp and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P50391
Residue number A
114
Residue number B
201
Peptide name
Neuropeptide Y receptor type 4

Ligandability

Cysteine 114 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 4 between cysteines 61 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
7x9c
Structure name
cryo-em structure of neuropeptide y y4 receptor in complex with pp and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
13
Peptide accession
P50391
Residue number A
61
Residue number B
64
Peptide name
Neuropeptide Y receptor type 4

Ligandability

Cysteine 61 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 4 between cysteines 91 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7x9c
Structure name
cryo-em structure of neuropeptide y y4 receptor in complex with pp and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
60
Peptide accession
P50391
Residue number A
91
Residue number B
316
Peptide name
Neuropeptide Y receptor type 4

Ligandability

Cysteine 91 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 4 between cysteines 91 and 94. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7x9c
Structure name
cryo-em structure of neuropeptide y y4 receptor in complex with pp and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
84
Peptide accession
P50391
Residue number A
91
Residue number B
94
Peptide name
Neuropeptide Y receptor type 4

Ligandability

Cysteine 91 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 94 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 4 between cysteines 94 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7x9c
Structure name
cryo-em structure of neuropeptide y y4 receptor in complex with pp and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
100
Peptide accession
P50391
Residue number A
94
Residue number B
122
Peptide name
Neuropeptide Y receptor type 4

Ligandability

Cysteine 94 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Neuropeptide Y receptor type 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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