a tool for identifying drug-targetable redox-active disulphides

Peroxisomal targeting signal 1 receptor

Intramolecular

Cysteine 492 and cysteine 510

A redox-regulated disulphide may form within Peroxisomal targeting signal 1 receptor between cysteines 492 and 510 (455 and 473 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

31

PDB code

Structure name

apo form of the tpr domain of the pex5p receptor

Structure deposition date

2005-09-05

Thiol separation (Å)

9

Half-sphere exposure sum ?

79

Minimum pK_a ?

12

% buried

90

Peptide accession

Residue number A

492

Residue number B

510

Peptide name

Peroxisomal targeting signal 1 receptor

Ligandability

Cysteine 492 of Peroxisomal targeting signal 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Peroxisomal targeting signal 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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