ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein Tob1

Intermolecular
Cysteine 202 of CCR4-NOT transcription complex subunit 7 and cysteine 57
A redox-regulated disulphide may form between cysteine 202 of CCR4-NOT transcription complex subunit 7 and cysteine 57 of Protein Tob1 (202 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2d5r
Structure name
crystal structure of a tob-hcaf1 complex
Structure deposition date
2005-11-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide A name
CCR4-NOT transcription complex subunit 7
Peptide B name
Protein Tob1
Peptide A accession
Q9UIV1
Peptide B accession
P50616
Peptide A residue number
202
Peptide B residue number
57

Ligandability

Cysteine 202 of CCR4-NOT transcription complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Protein Tob1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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