E3 ubiquitin-protein ligase RNF144A
Intramolecular
Cysteine 38 and cysteine 70
Cysteine 40 and cysteine 70
Cysteine 65 and cysteine 70
Cysteine 20 and cysteine 23
Cysteine 38 and cysteine 40
Cysteine 20 and cysteine 46
Cysteine 20 and cysteine 43
Cysteine 38 and cysteine 65
Cysteine 23 and cysteine 46
Cysteine 23 and cysteine 43
More...Cysteine 43 and cysteine 46
Cysteine 40 and cysteine 65
Cysteine 20 and cysteine 65
1wim A 26 A 58
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 38 and 70 (26 and 58 respectively in this structure).
Details
Redox score ?
90
PDB code
1wim
Structure name
solution structure of the ring finger domain of the human ubcm4- interacting protein 4
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
6
% buried
3
Peptide accession
P50876
Residue number A
38
Residue number B
70
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 38 of E3 ubiquitin-protein ligase RNF144A
Cysteine 70 of E3 ubiquitin-protein ligase RNF144A
1wim A 28 A 58
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 40 and 70 (28 and 58 respectively in this structure).
Details
Redox score ?
89
PDB code
1wim
Structure name
solution structure of the ring finger domain of the human ubcm4- interacting protein 4
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
2
Peptide accession
P50876
Residue number A
40
Residue number B
70
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 40 of E3 ubiquitin-protein ligase RNF144A
Cysteine 70 of E3 ubiquitin-protein ligase RNF144A
6l99 A 53 A 58
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 65 and 70 (53 and 58 respectively in this structure).
Details
Redox score ?
87
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
8
Peptide accession
P50876
Residue number A
65
Residue number B
70
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 65 of E3 ubiquitin-protein ligase RNF144A
Cysteine 70 of E3 ubiquitin-protein ligase RNF144A
6l99 A 8 A 11
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 20 and 23 (8 and 11 respectively in this structure).
Details
Redox score ?
86
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
6
Peptide accession
P50876
Residue number A
20
Residue number B
23
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 20 of E3 ubiquitin-protein ligase RNF144A
Cysteine 23 of E3 ubiquitin-protein ligase RNF144A
6l99 A 26 A 28
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 38 and 40 (26 and 28 respectively in this structure).
Details
Redox score ?
86
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
6
Peptide accession
P50876
Residue number A
38
Residue number B
40
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 38 of E3 ubiquitin-protein ligase RNF144A
Cysteine 40 of E3 ubiquitin-protein ligase RNF144A
6l99 A 8 A 34
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 20 and 46 (8 and 34 respectively in this structure).
Details
Redox score ?
84
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
10
Peptide accession
P50876
Residue number A
20
Residue number B
46
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 20 of E3 ubiquitin-protein ligase RNF144A
Cysteine 46 of E3 ubiquitin-protein ligase RNF144A
6l99 A 8 A 31
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 20 and 43 (8 and 31 respectively in this structure).
Details
Redox score ?
84
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
10
Peptide accession
P50876
Residue number A
20
Residue number B
43
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 20 of E3 ubiquitin-protein ligase RNF144A
Cysteine 43 of E3 ubiquitin-protein ligase RNF144A
1wim A 26 A 53
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 38 and 65 (26 and 53 respectively in this structure).
Details
Redox score ?
82
PDB code
1wim
Structure name
solution structure of the ring finger domain of the human ubcm4- interacting protein 4
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
12
Peptide accession
P50876
Residue number A
38
Residue number B
65
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 38 of E3 ubiquitin-protein ligase RNF144A
Cysteine 65 of E3 ubiquitin-protein ligase RNF144A
6l99 A 11 A 34
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 23 and 46 (11 and 34 respectively in this structure).
Details
Redox score ?
81
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
4
Peptide accession
P50876
Residue number A
23
Residue number B
46
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 23 of E3 ubiquitin-protein ligase RNF144A
Cysteine 46 of E3 ubiquitin-protein ligase RNF144A
1wim A 11 A 31
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 23 and 43 (11 and 31 respectively in this structure).
Details
Redox score ?
80
PDB code
1wim
Structure name
solution structure of the ring finger domain of the human ubcm4- interacting protein 4
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
4
Peptide accession
P50876
Residue number A
23
Residue number B
43
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 23 of E3 ubiquitin-protein ligase RNF144A
Cysteine 43 of E3 ubiquitin-protein ligase RNF144A
1wim A 31 A 34
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 43 and 46 (31 and 34 respectively in this structure).
Details
Redox score ?
79
PDB code
1wim
Structure name
solution structure of the ring finger domain of the human ubcm4- interacting protein 4
Structure deposition date
2004-05-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
10
Peptide accession
P50876
Residue number A
43
Residue number B
46
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 43 of E3 ubiquitin-protein ligase RNF144A
Cysteine 46 of E3 ubiquitin-protein ligase RNF144A
1wim A 28 A 53
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 40 and 65 (28 and 53 respectively in this structure).
Details
Redox score ?
76
PDB code
1wim
Structure name
solution structure of the ring finger domain of the human ubcm4- interacting protein 4
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
12
Peptide accession
P50876
Residue number A
40
Residue number B
65
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 40 of E3 ubiquitin-protein ligase RNF144A
Cysteine 65 of E3 ubiquitin-protein ligase RNF144A
6l99 A 8 A 53
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF144A between cysteines 20 and 65 (8 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6l99
Structure name
zinc finger of ring finger protein 144a
Structure deposition date
2019-11-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
14
Peptide accession
P50876
Residue number A
20
Residue number B
65
Peptide name
E3 ubiquitin-protein ligase RNF144A
Ligandability
Cysteine 20 of E3 ubiquitin-protein ligase RNF144A
Cysteine 65 of E3 ubiquitin-protein ligase RNF144A
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