ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-complex protein 1 subunit delta

Intramolecular
Cysteine 410 and cysteine 414
Cysteine 120 and cysteine 450 L
A redox-regulated disulphide may form within T-complex protein 1 subunit delta between cysteines 410 and 414. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6nrc
Structure name
htric-hpfd class3
Structure deposition date
2019-01-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
P50991
Residue number A
410
Residue number B
414
Peptide name
T-complex protein 1 subunit delta

Ligandability

Cysteine 410 of T-complex protein 1 subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 414 of T-complex protein 1 subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-complex protein 1 subunit delta between cysteines 120 and 450. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7lup
Structure name
human tric/cct complex with reovirus outer capsid protein sigma-3
Structure deposition date
2021-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
86
Peptide accession
P50991
Residue number A
120
Residue number B
450
Peptide name
T-complex protein 1 subunit delta

Ligandability

Cysteine 120 of T-complex protein 1 subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of T-complex protein 1 subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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