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Amiloride-sensitive sodium channel subunit beta

Intramolecular
Cysteine 196 and cysteine 203
Cysteine 386 and cysteine 444
Cysteine 361 and cysteine 448
Cysteine 399 and cysteine 426
Cysteine 184 and cysteine 189
Cysteine 390 and cysteine 440
Cysteine 401 and cysteine 415
Cysteine 249 and cysteine 256
Cysteine 98 and cysteine 272
Cysteine 440 and cysteine 444
More...
Cysteine 399 and cysteine 401
Cysteine 399 and cysteine 415
Cysteine 390 and cysteine 444
Cysteine 386 and cysteine 440
Cysteine 386 and cysteine 390
Cysteine 401 and cysteine 426
Cysteine 415 and cysteine 426
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 196 and 203.

Details

Redox score ?
85
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
196
Residue number B
203
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 196 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 386 and 444.

Details

Redox score ?
84
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
386
Residue number B
444
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 386 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 361 and 448.

Details

Redox score ?
84
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
361
Residue number B
448
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 361 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 448 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 399 and 426.

Details

Redox score ?
83
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
399
Residue number B
426
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 399 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 426 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 184 and 189.

Details

Redox score ?
83
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
184
Residue number B
189
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 184 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 390 and 440.

Details

Redox score ?
81
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
390
Residue number B
440
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 390 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 440 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 401 and 415.

Details

Redox score ?
81
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
401
Residue number B
415
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 401 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 415 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 249 and 256.

Details

Redox score ?
80
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
249
Residue number B
256
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 249 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 256 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 98 and 272.

Details

Redox score ?
80
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
98
Residue number B
272
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 98 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 440 and 444.

Details

Redox score ?
74
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
440
Residue number B
444
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 440 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 399 and 401.

Details

Redox score ?
72
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
399
Residue number B
401
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 399 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 401 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 399 and 415.

Details

Redox score ?
67
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
399
Residue number B
415
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 399 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 415 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 390 and 444.

Details

Redox score ?
66
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
390
Residue number B
444
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 390 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 386 and 440.

Details

Redox score ?
65
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
386
Residue number B
440
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 386 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 440 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 386 and 390.

Details

Redox score ?
60
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
386
Residue number B
390
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 386 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 401 and 426. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
401
Residue number B
426
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 401 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 426 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit beta between cysteines 415 and 426. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51168
Residue number A
415
Residue number B
426
Peptide name
Amiloride-sensitive sodium channel subunit beta

Ligandability

Cysteine 415 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 426 of Amiloride-sensitive sodium channel subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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