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Amiloride-sensitive sodium channel subunit gamma

Intramolecular
Cysteine 207 and cysteine 214
Cysteine 372 and cysteine 457
Cysteine 394 and cysteine 453
Cysteine 407 and cysteine 434
Cysteine 398 and cysteine 449
Cysteine 409 and cysteine 423
Cysteine 100 and cysteine 283
Cysteine 260 and cysteine 267
Cysteine 398 and cysteine 453
Cysteine 449 and cysteine 453
More...
Cysteine 407 and cysteine 409
Cysteine 394 and cysteine 398
Cysteine 409 and cysteine 434
Cysteine 394 and cysteine 449
Cysteine 407 and cysteine 423
Cysteine 423 and cysteine 434
A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 207 and 214.

Details

Redox score ?
85
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
207
Residue number B
214
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 207 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 372 and 457.

Details

Redox score ?
84
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
372
Residue number B
457
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 372 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 457 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 394 and 453.

Details

Redox score ?
84
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
394
Residue number B
453
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 394 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 407 and 434.

Details

Redox score ?
82
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
407
Residue number B
434
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 407 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 398 and 449.

Details

Redox score ?
81
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
398
Residue number B
449
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 398 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 449 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 409 and 423.

Details

Redox score ?
81
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
409
Residue number B
423
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 409 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 100 and 283.

Details

Redox score ?
80
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
100
Residue number B
283
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 100 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 260 and 267.

Details

Redox score ?
79
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
260
Residue number B
267
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 260 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 267 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 398 and 453.

Details

Redox score ?
62
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
398
Residue number B
453
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 398 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 449 and 453.

Details

Redox score ?
61
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
449
Residue number B
453
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 449 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 407 and 409. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
407
Residue number B
409
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 407 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 409 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 394 and 398. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
394
Residue number B
398
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 394 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 409 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
409
Residue number B
434
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 409 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 394 and 449. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
394
Residue number B
449
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 394 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 449 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 407 and 423. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
407
Residue number B
423
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 407 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amiloride-sensitive sodium channel subunit gamma between cysteines 423 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6wth
Structure name
full-length human enac ecd
Structure deposition date
2020-05-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51170
Residue number A
423
Residue number B
434
Peptide name
Amiloride-sensitive sodium channel subunit gamma

Ligandability

Cysteine 423 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Amiloride-sensitive sodium channel subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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