ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Intramolecular
Cysteine 344 and cysteine 393
Cysteine 337 and cysteine 339
Cysteine 339 and cysteine 499
A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 between cysteines 344 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1djy
Structure name
phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-2,4,5-trisphosphate
Structure deposition date
1996-08-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
82
Peptide accession
P10688
Residue number A
344
Residue number B
393
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Ligandability

Cysteine 344 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 between cysteines 337 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1djw
Structure name
phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-2-methylene-1,2-cyclic- monophosphonate
Structure deposition date
1996-08-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
100
Peptide accession
P10688
Residue number A
337
Residue number B
339
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Ligandability

Cysteine 337 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 between cysteines 339 and 499. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1djz
Structure name
phosphoinositide-specific phospholipase c-delta1 from rat complexed with inositol-4,5-bisphosphate
Structure deposition date
1996-08-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
P10688
Residue number A
339
Residue number B
499
Peptide name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Ligandability

Cysteine 339 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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