ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Transcription activator BRG1

Intermolecular
Cysteine 423 and cysteine 492 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 L
Intramolecular
Cysteine 998 and cysteine 1046
Cysteine 1046 and cysteine 1205
Cysteine 998 and cysteine 1205
Cysteine 1046 and cysteine 1103
A redox-regulated disulphide may form between cysteine 423 of Transcription activator BRG1 and cysteine 492 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7y8r
Structure name
the nucleosome-bound human pbaf complex
Structure deposition date
2022-06-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
34
Peptide A name
Transcription activator BRG1
Peptide B name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Peptide A accession
P51532
Peptide B accession
Q96GM5
Peptide A residue number
423
Peptide B residue number
492

Ligandability

Cysteine 423 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 492 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription activator BRG1 between cysteines 998 and 1046. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6ltj
Structure name
structure of nucleosome-bound human baf complex
Structure deposition date
2020-01-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
54
Peptide accession
P51532
Residue number A
998
Residue number B
1046
Peptide name
Transcription activator BRG1

Ligandability

Cysteine 998 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1046 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription activator BRG1 between cysteines 1046 and 1205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6ltj
Structure name
structure of nucleosome-bound human baf complex
Structure deposition date
2020-01-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
30
Peptide accession
P51532
Residue number A
1046
Residue number B
1205
Peptide name
Transcription activator BRG1

Ligandability

Cysteine 1046 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1205 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription activator BRG1 between cysteines 998 and 1205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7vdt
Structure name
the motor-nucleosome module of human chromatin remodeling pbaf- nucleosome complex
Structure deposition date
2021-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
90
Peptide accession
P51532
Residue number A
998
Residue number B
1205
Peptide name
Transcription activator BRG1

Ligandability

Cysteine 998 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1205 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription activator BRG1 between cysteines 1046 and 1103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6ltj
Structure name
structure of nucleosome-bound human baf complex
Structure deposition date
2020-01-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
66
Peptide accession
P51532
Residue number A
1046
Residue number B
1103
Peptide name
Transcription activator BRG1

Ligandability

Cysteine 1046 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1103 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: