ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Galactokinase

Intermolecular
Cysteine 391 and cysteine 391
Intramolecular
Cysteine 170 and cysteine 182 L
A redox-regulated disulphide may form between two units of Galactokinase at cysteines 391 and 391.

Details

Redox score ?
73
PDB code
7ozx
Structure name
structure of human galactokinase 1 bound with azepan-1-yl(2,6- difluorophenyl)methanone
Structure deposition date
2021-06-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
91
Peptide A name
Galactokinase
Peptide B name
Galactokinase
Peptide A accession
P51570
Peptide B accession
P51570
Peptide A residue number
391
Peptide B residue number
391

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galactokinase between cysteines 170 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
6gr2
Structure name
structure of human galactokinase in complex with galactose and adp
Structure deposition date
2018-06-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
P51570
Residue number A
170
Residue number B
182
Peptide name
Galactokinase

Ligandability

Cysteine 170 of Galactokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Galactokinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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