a tool for identifying drug-targetable redox-active disulphides

Host cell factor 1

Intramolecular

Cysteine 1963 and cysteine 1969

A redox-regulated disulphide may form within Host cell factor 1 between cysteines 1963 and 1969 (69 and 75 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

40

PDB code

Structure name

nmr structure of the c-terminal domain of the protein hcfc1 from mus musculus

Structure deposition date

2012-12-14

Thiol separation (Å)

10

Half-sphere exposure sum ?

48

Minimum pK_a ?

9

% buried

10

Peptide accession

Residue number A

1963

Residue number B

1969

Peptide name

Host cell factor 1

Ligandability

Cysteine 1963 of Host cell factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1969 of Host cell factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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