Interleukin-1 receptor-associated kinase 1
Intramolecular
Cysteine 278 and cysteine 285
Cysteine 199 and cysteine 278
Cysteine 302 and cysteine 307 L
Cysteine 498 and cysteine 499
Cysteine 203 and cysteine 278 L
Cysteine 499 and cysteine 500
Cysteine 498 and cysteine 500
6bfn A 278 A 285
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 278 and 285. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
70
Peptide accession
P51617
Residue number A
278
Residue number B
285
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 278 of Interleukin-1 receptor-associated kinase 1
Cysteine 285 of Interleukin-1 receptor-associated kinase 1
6bfn B 199 B 278
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 199 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
37
Peptide accession
P51617
Residue number A
199
Residue number B
278
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 199 of Interleukin-1 receptor-associated kinase 1
Cysteine 278 of Interleukin-1 receptor-associated kinase 1
6bfn B 302 B 307
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 302 and 307. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P51617
Residue number A
302
Residue number B
307
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 302 of Interleukin-1 receptor-associated kinase 1
Cysteine 307 of Interleukin-1 receptor-associated kinase 1
6bfn B 498 B 499
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 498 and 499. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
72
Peptide accession
P51617
Residue number A
498
Residue number B
499
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 498 of Interleukin-1 receptor-associated kinase 1
Cysteine 499 of Interleukin-1 receptor-associated kinase 1
6bfn B 203 B 278
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 203 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
22
Peptide accession
P51617
Residue number A
203
Residue number B
278
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 203 of Interleukin-1 receptor-associated kinase 1
Cysteine 278 of Interleukin-1 receptor-associated kinase 1
6bfn A 499 A 500
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 499 and 500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
80
Peptide accession
P51617
Residue number A
499
Residue number B
500
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 499 of Interleukin-1 receptor-associated kinase 1
Cysteine 500 of Interleukin-1 receptor-associated kinase 1
6bfn A 498 A 500
A redox-regulated disulphide may form within Interleukin-1 receptor-associated kinase 1 between cysteines 498 and 500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
6bfn
Structure name
crystal structure of human irak1
Structure deposition date
2017-10-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
92
Peptide accession
P51617
Residue number A
498
Residue number B
500
Peptide name
Interleukin-1 receptor-associated kinase 1
Ligandability
Cysteine 498 of Interleukin-1 receptor-associated kinase 1
Cysteine 500 of Interleukin-1 receptor-associated kinase 1
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