ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Succinate-semialdehyde dehydrogenase, mitochondrial

Intramolecular
Cysteine 93 and cysteine 259
Cysteine 340 and cysteine 342 L
A redox-regulated disulphide may form within Succinate-semialdehyde dehydrogenase, mitochondrial between cysteines 93 and 259. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2w8p
Structure name
the crystal structure of human c340a ssadh
Structure deposition date
2009-01-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
83
Peptide accession
P51649
Residue number A
93
Residue number B
259
Peptide name
Succinate-semialdehyde dehydrogenase, mitochondrial

Ligandability

Cysteine 93 of Succinate-semialdehyde dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Succinate-semialdehyde dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate-semialdehyde dehydrogenase, mitochondrial between cysteines 340 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2w8o
Structure name
the crystal structure of the reduced form of human ssadh
Structure deposition date
2009-01-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
P51649
Residue number A
340
Residue number B
342
Peptide name
Succinate-semialdehyde dehydrogenase, mitochondrial

Ligandability

Cysteine 340 of Succinate-semialdehyde dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Succinate-semialdehyde dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: