ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-C chemokine receptor type 3

Intramolecular
Cysteine 106 and cysteine 183
Cysteine 294 and cysteine 295
A redox-regulated disulphide may form within C-C chemokine receptor type 3 between cysteines 106 and 183.

Details

Redox score ?
78
PDB code
7x9y
Structure name
cryo-em structure of the apo ccr3-gi complex
Structure deposition date
2022-03-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
46
Peptide accession
P51677
Residue number A
106
Residue number B
183
Peptide name
C-C chemokine receptor type 3

Ligandability

Cysteine 106 of C-C chemokine receptor type 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of C-C chemokine receptor type 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-C chemokine receptor type 3 between cysteines 294 and 295.

Details

Redox score ?
69
PDB code
7x9y
Structure name
cryo-em structure of the apo ccr3-gi complex
Structure deposition date
2022-03-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
8
% buried
78
Peptide accession
P51677
Residue number A
294
Residue number B
295
Peptide name
C-C chemokine receptor type 3

Ligandability

Cysteine 294 of C-C chemokine receptor type 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of C-C chemokine receptor type 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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