ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ubiquitin carboxyl-terminal hydrolase 11

Intermolecular
Cysteine 204 and cysteine 204
Cysteine 214 and cysteine 214 L
A redox-regulated disulphide may form between two units of Ubiquitin carboxyl-terminal hydrolase 11 at cysteines 204 and 204.

Details

Redox score ?
83
PDB code
4mem
Structure name
crystal structure of the rat usp11 dusp-ubl domains
Structure deposition date
2013-08-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ubiquitin carboxyl-terminal hydrolase 11
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 11
Peptide A accession
Q5D006
Peptide B accession
Q5D006
Peptide A residue number
204
Peptide B residue number
204

Ligandability

A redox-regulated disulphide may form between two units of Ubiquitin carboxyl-terminal hydrolase 11 at cysteines 214 and 214. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4mem
Structure name
crystal structure of the rat usp11 dusp-ubl domains
Structure deposition date
2013-08-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
20
Peptide A name
Ubiquitin carboxyl-terminal hydrolase 11
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 11
Peptide A accession
Q5D006
Peptide B accession
Q5D006
Peptide A residue number
214
Peptide B residue number
214

Ligandability

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