a tool for identifying drug-targetable redox-active disulphides

H(+)/Cl(-) exchange transporter 7

Intramolecular

Cysteine 438 and cysteine 454

A redox-regulated disulphide may form within H(+)/Cl(-) exchange transporter 7 between cysteines 438 and 454.

Details

Redox score ?

72

PDB code

Structure name

clc-7/ostm1 membrane protein complex

Structure deposition date

2020-04-20

Thiol separation (Å)

5

Half-sphere exposure sum ?

57

Minimum pK_a ?

10

% buried

28

Peptide accession

Residue number A

438

Residue number B

454

Peptide name

H(+)/Cl(-) exchange transporter 7

Ligandability

Cysteine 438 of H(+)/Cl(-) exchange transporter 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 454 of H(+)/Cl(-) exchange transporter 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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