a tool for identifying drug-targetable redox-active disulphides

Vesicle-associated membrane protein 7

Intermolecular

Cysteine 21 and cysteine 21

A redox-regulated disulphide may form between two units of Vesicle-associated membrane protein 7 at cysteines 21 and 21 (64 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

vamp7 longin domain hrb peptide complex

Structure deposition date

2008-07-01

Thiol separation (Å)

6

Half-sphere exposure sum ?

65

Minimum pK_a ?

12

% buried

74

Peptide A name

Vesicle-associated membrane protein 7

Peptide B name

Vesicle-associated membrane protein 7

Peptide A accession

Peptide B accession

Peptide A residue number

21

Peptide B residue number

21

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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