CDK-activating kinase assembly factor MAT1
Intramolecular
Cysteine 6 and cysteine 9
Cysteine 6 and cysteine 34
Cysteine 6 and cysteine 31
Cysteine 46 and cysteine 49
Cysteine 26 and cysteine 46
Cysteine 26 and cysteine 49
Cysteine 9 and cysteine 34
Cysteine 31 and cysteine 34
Cysteine 9 and cysteine 31
Cysteine 34 and cysteine 46
Cysteine 6 and cysteine 46
1g25 A 6 A 9
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 6 and 9.
Details
Redox score ?
80
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
24
Peptide accession
P51948
Residue number A
6
Residue number B
9
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 6 of CDK-activating kinase assembly factor MAT1
Cysteine 9 of CDK-activating kinase assembly factor MAT1
1g25 A 6 A 34
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 6 and 34.
Details
Redox score ?
79
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
36
Peptide accession
P51948
Residue number A
6
Residue number B
34
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 6 of CDK-activating kinase assembly factor MAT1
Cysteine 34 of CDK-activating kinase assembly factor MAT1
1g25 A 6 A 31
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 6 and 31.
Details
Redox score ?
79
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
30
Peptide accession
P51948
Residue number A
6
Residue number B
31
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 6 of CDK-activating kinase assembly factor MAT1
Cysteine 31 of CDK-activating kinase assembly factor MAT1
1g25 A 46 A 49
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 46 and 49.
Details
Redox score ?
79
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
7
Peptide accession
P51948
Residue number A
46
Residue number B
49
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 46 of CDK-activating kinase assembly factor MAT1
Cysteine 49 of CDK-activating kinase assembly factor MAT1
1g25 A 26 A 46
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 26 and 46.
Details
Redox score ?
78
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
7
Peptide accession
P51948
Residue number A
26
Residue number B
46
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 26 of CDK-activating kinase assembly factor MAT1
Cysteine 46 of CDK-activating kinase assembly factor MAT1
1g25 A 26 A 49
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 26 and 49.
Details
Redox score ?
78
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
0
Peptide accession
P51948
Residue number A
26
Residue number B
49
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 26 of CDK-activating kinase assembly factor MAT1
Cysteine 49 of CDK-activating kinase assembly factor MAT1
1g25 A 9 A 34
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 9 and 34.
Details
Redox score ?
75
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
34
Peptide accession
P51948
Residue number A
9
Residue number B
34
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 9 of CDK-activating kinase assembly factor MAT1
Cysteine 34 of CDK-activating kinase assembly factor MAT1
1g25 A 31 A 34
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 31 and 34.
Details
Redox score ?
72
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
41
Peptide accession
P51948
Residue number A
31
Residue number B
34
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 31 of CDK-activating kinase assembly factor MAT1
Cysteine 34 of CDK-activating kinase assembly factor MAT1
1g25 A 9 A 31
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 9 and 31.
Details
Redox score ?
70
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
28
Peptide accession
P51948
Residue number A
9
Residue number B
31
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 9 of CDK-activating kinase assembly factor MAT1
Cysteine 31 of CDK-activating kinase assembly factor MAT1
1g25 A 34 A 46
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 34 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
1g25
Structure name
solution structure of the n-terminal domain of the human tfiih mat1 subunit
Structure deposition date
2000-10-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
30
Peptide accession
P51948
Residue number A
34
Residue number B
46
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 34 of CDK-activating kinase assembly factor MAT1
Cysteine 46 of CDK-activating kinase assembly factor MAT1
7nvr 3 6 3 46
A redox-regulated disulphide may form within CDK-activating kinase assembly factor MAT1 between cysteines 6 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7nvr
Structure name
human mediator with rna polymerase ii pre-initiation complex
Structure deposition date
2021-03-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
nan
Peptide accession
P51948
Residue number A
6
Residue number B
46
Peptide name
CDK-activating kinase assembly factor MAT1
Ligandability
Cysteine 6 of CDK-activating kinase assembly factor MAT1
Cysteine 46 of CDK-activating kinase assembly factor MAT1
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